Three teams that entered last week winless picked up their first victories of the season: the Giants, Jets and Colts. All three are underdogs to get win No. 2 in the Week 5 NFL odds at Caesars Sportsbook. The Giants are 7.5-point underdogs as they take on the rival Cowboys, while the Baltimore Ravens are seven-point favorites over the Colts. These are two of the five games on the Week 5 NFL schedule in which the NFL Vegas odds are at least a touchdown.

Meanwhile, after Zach Wilson and Robert Saleh picked up their first career wins, the Jets are still getting points against the Falcons in the Week 5 NFL spreads. Atlanta is a 3.5-point favorite over New York as both teams look for their second wins of the season. Should any of these NFL matchups be considered in your Week 5 NFL bets? All of the NFL lines are listed below, and before making any Week 5 NFL picks on these games or others, be sure to see the Week 5 NFL predictions from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 5 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 5 NFL predictions

One of the top Week 5 NFL predictions the model recommends: The Patriots (-9.5) cover the spread against the Texans in almost 60 percent of simulations. Patriots’ rookie quarterback Mac Jones took a major step forward in Week 4 despite his team’s loss to the Buccaneers. Jones completed 19 straight passes in the game, the longest streak by a rookie in 40 years. He finished the game with a 77.5 completion percentage and two touchdowns, both career-highs.

The Patriots’ defense is among the best in the league, ranking sixth in points allowed and fifth in yards allowed. Those rankings are likely to get even better when they venture to Houston, which has among the league’s worst offenses. The Texans had an abysmal showing in Week 4, as they were shut out 40-0 to the Bills. Houston has scored just one touchdown over its last two games, while rookie quarterback Davis Mills ranks third in interceptions (five) despite ranking 31st in pass attempts (67).

The model foresees one rookie quarterback impressing while the other struggles. It has Jones remaining efficient with a nearly 75 percent completion percentage as he approaches 300 yards. Mills is projected to complete under 60 percent of his passes and finish with more interceptions than touchdowns. The model also acknowledges that the Texans’ point differential has increased in each game and the team failed to cover the spread in its last two contests.

Another one of its Week 5 NFL predictions: The Packers (-3.5) cover on the road against the Bengals in a matchup of 3-1 teams. After a shocking performance in Week 1, the Packers we are accustomed to seeing have shown up in the last three games. Green Bay’s defense has multiple takeaways in those three wins, while the offense has committed just one total turnover.

On the other hand, Cincinnati has committed more turnovers (five) than it has takeaways (four) despite playing a soft schedule thus far. The Bengals’ four opponents have a combined 4-12 record and none of them is over .500. While the Bengals have shown balance on the offensive side of the ball, that could disappear if running back Joe Mixon (ankle) is unable to play. He is listed as week-to-week but has a history of injuries lingering and keeping him out of multiple games.

SportsLine’s model projects Green Bay’s offense controlling the game as wide receiver Davante Adams goes for over 100 yards while running backs Aaron Jones and AJ Dillon average almost 5.0 yards per carry. Cincinnati’s offense is unable to keep up and the model has Green Bay covering in well over 50 percent of simulations. The model also says you should back the Over (49.5), which hits in almost 60 percent of simulations.

How to make Week 5 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 5 NFL schedule, and it’s calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.

Week 5 NFL odds, spreads, lines

Thursday, Oct. 7

Rams at Seahawks (+1.5, 54.5)

Featured Game | Seattle Seahawks vs. Los Angeles Rams

Sunday, Oct. 10

Jets at Falcons (-3.5, 44)

Featured Game | Atlanta Falcons vs. New York Jets

Dolphins at Buccaneers (-10.5, 48)

Featured Game | Tampa Bay Buccaneers vs. Miami Dolphins

Eagles at Panthers (-4, 45.5)

Featured Game | Carolina Panthers vs. Philadelphia Eagles

Saints at Washington (+1, 44.5)

Featured Game | Washington Football Team vs. New Orleans Saints

Titans at Jaguars (+4, 48.5)

Featured Game | Jacksonville Jaguars vs. Tennessee Titans

Lions at Vikings (-8, 49.5)

Featured Game | Minnesota Vikings vs. Detroit Lions

Broncos at Steelers (-1, 40.5)

Featured Game | Pittsburgh Steelers vs. Denver Broncos

Packers at Bengals (+3.5, 49.5)

Featured Game | Cincinnati Bengals vs. Green Bay Packers

Patriots at Texans (+9.5, 39.5)

Featured Game | Houston Texans vs. New England Patriots

Bears at Raiders (-4.5, 45.5)

Featured Game | Las Vegas Raiders vs. Chicago Bears

Browns at Chargers (PK, 49.5)

Featured Game | Los Angeles Chargers vs. Cleveland Browns

Giants at Cowboys (-7.5, 51)

Featured Game | Dallas Cowboys vs. New York Giants

49ers at Cardinals (-5, 53)

Featured Game | Arizona Cardinals vs. San Francisco 49ers

Bills at Chiefs (-2.5, 56.5)

Featured Game | Kansas City Chiefs vs. Buffalo Bills

Monday, Oct. 11

Colts at Ravens (-7, 48)

Featured Game | Baltimore Ravens vs. Indianapolis Colts


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