Browns vs. Jaguars odds, picks: 2021 NFL preseason Week 1 predictions, best bets from expert on 23-12 run

The Cleveland Browns look to build on last year’s success as they open their 2021 NFL preseason schedule against the Jacksonville Jaguars on Saturday. The Browns, who finished tied for second in the AFC North with the Baltimore Ravens at 11-5, advanced to the AFC Divisional round of the playoffs before losing 22-17 to the Kansas City Chiefs. The Jaguars, meanwhile, finished fourth in the AFC South at 1-15. Jacksonville leads the regular-season series 12-6. This is the first time the teams have met in the preseason.

Kickoff from TIAA Bank Field in Jacksonville, Fla., is set for 7 p.m. ET. Jacksonville is a 2.5-point favorite in the latest Browns vs. Jaguars odds from Caesars Sportsbook, while the over-under for total points scored is set at 37. Before making any Jaguars vs. Browns picks or NFL preseason bets, make sure you check out what SportsLine NFL expert, Mike Tierney, has to say.

A national sportswriter whose work appears in The New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. He’s crushed his NFL picks, going 187-147 against the spread (56 percent) the past three seasons. All-time at SportsLine (2016-20), Tierney is 347-291 on all NFL picks, returning $2,534 to $100 players.

Tierney has had a lot of success in games involving the Jacksonville Jaguars. He went 23-12 in his last 35 against-the-spread NFL picks in Jacksonville games, returning $1,013 to $100 players. Anybody who has been following him is way up.

Now, Tierney has locked in another confident against the spread pick for the Browns vs. Jaguars matchup. You need to see what it is and check out Tierney’s expert analysis before locking in any Jaguars vs. Browns picks of your own. Here are the NFL preseason betting odds, lines, and trends for Browns vs. Jaguars:

  • Browns vs. Jaguars spread: Jacksonville -2.5 
  • Browns vs. Jaguars over-under: 37 points 
  • Browns vs. Jaguars money line: Cleveland +130, Jacksonville -150 
  • CLE: The Browns are 4-1 against the spread in their last five games as road underdogs 
  • JAX: The Jaguars are 6-2 ATS in their last eight Saturday games 

Featured Game | Jacksonville Jaguars vs. Cleveland Browns

Why the Jaguars can cover

After suffering through a dismal 2020 season, new coach Urban Meyer wants to see what kind of team he has at his disposal. He also wants a sneak preview of his quarterback situation, so look for both top draft pick Trevor Lawrence and veteran Gardner Minshew to see action. 

Lawrence was outstanding in his career at Clemson. Last season, he completed 231 of 334 passes (69.2 percent) for 3,153 yards and 24 touchdowns. He was intercepted five times and had a quarterback rating of 169.2.

Minshew played in nine games last year and led the Jaguars in passing. He completed 216-of-327 passes (66.1 percent) for 2,259 yards and 16 touchdowns, while throwing five picks. He had a rating of 95.9. 

Why the Browns can cover 

Cleveland has more depth, especially if not many of the starters play much on either team. Coach Kevin Stefanski already has made it clear that starting QB Baker Mayfield won’t play much, if at all. That means both Case Keenum and former New York Giants fourth-round draft pick Kyle Lauletta will get time under center.

Keenum played in just two games last season for the Browns, completing five-of-10 passes for 46 yards. This is his 10th season in the NFL after stops in Houston, with the Rams, Minnesota, Denver, Washington and Cleveland. He has completed 62.3 percent of his passes and thrown for 14,414 yards with 75 touchdowns and 47 interceptions. His best season was in 2017 with the Vikings. In 15 games, he completed 325 of 481 passes (67.6 percent) for 3,547 yards, 22 touchdowns and seven interceptions.

How to make Browns vs. Jaguars picks

Tierney has analyzed this matchup from all angles and has discovered a critical X-factor that has him jumping all over one side of the spread. You can only get Tierney’s expert NFL picks at SportsLine.

Who wins Browns vs. Jaguars? And what critical x-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Browns vs. Jaguars spread you need to jump on Saturday, all from the expert who returned $1,013 to $100 players in the last 35 Jacksonville Jaguars picks, and find out.

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